Ohio State - Nationwide Children's Hospital - Research For Muscle Biology and Disease
 

2014 MVIMG 7470

Neuromuscular Biology and Disease – Duchenne Muscular Dystrophy

Thursdays 2:30-3:30pm, Parks Hall 103

Instructors: Jill Rafael-Fortney, PhD and Denis Guttridge, PhD

Course schedule:
2014 MVIMG 7470 course schedule

MVIMG 7470 Spring 2014 DMD Course Syllabus (download PDF)

WEEK 1 – Jan 9
Clinical / genetics / diagnosis overview - Kevin Flanigan, M.D.
History of dystrophin gene cloning - Arthur Burghes, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 2 – Jan 16
Overview of skeletal and cardiac muscle physiology and measurements - Paul Janssen, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 3 – Jan 23
Histopathology / pathophysiology overview - Zarife Sahenk, M.D., Ph.D. / Jill Rafael-Fortney, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 4 – Jan 30
Dystrophin glycoprotein complex discovery and associations - Rachelle Crosbie, Ph.D. (UCLA)



Click here to download a PDF of the slides used in this lecture.

WEEK 5 – Feb 6
Cardiomyopathy - Subha Raman, M.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 6 – Feb 13
Discussion of Darius Goes West - Denis Guttridge, Ph.D. and Jill Rafael-Fortney, Ph.D.
To watch the film Darius Goes West on-line, go to:
http://www.dariusgoeswest.org/playitforward/

WEEK 7 – Feb 20
Summary of preclinical and transgenic models - Jill Rafael-Fortney, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 8 – Feb 27
Membrane damage and repair - Noah Weisleder, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 9 – March 6
Glycosylation and membrane stabilization - Paul Martin, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 10 – March 20
Inflammation - Jim Tidball, Ph.D. (UCLA)



Click here to download a PDF of the slides used in this lecture.

WEEK 11 – March 27
Signaling pathways - Denis Guttridge, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 12 –April 3
Fibrosis - Federica Montanaro, Ph.D.



Click here to download a PDF of the slides used in this lecture.

WEEK 13 – April 10
Gene therapy / exon skipping / pre/neonatal-testing - Jerry Mendell, M.D.


WEEK 14 – April 17
Perspective from a parent and advocate - Pat Furlong, Parent Project Muscular Dystrophy