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Paul T. Martin , Ph.D.
Associate Professor
Center for Gene Therapy,
The Research Institute at Nationwide Children’s
Hospital,
700 Children’s Drive,
Columbus, OH 43205
Phone: (614) 722-4072
Fax: (614) 722-5893
Email:
MartinPT@pediatrics.ohio-state.edu
Education & Training:
University of California, Berkeley, Ph.D. in Biochemistry with
Daniel E. Koshland, Jr. Washington University Medical School, postdoctoral
fellow in Neurobiology with Joshua Sanes
Neurosciences at the University
of California, San Diego, Assistant and Associate Professor
Center for Gene
Therapy, and The Ohio State University Medical School, Associate Professor
of Pediatrics and of Physiology and Cell Biology
Research Interest:
Dr. Martin’s laboratory studies functional roles for glycosylation
in the mammalian development and in neuromuscular disorders. Current work
involves understanding therapeutic roles for glycosyltransferases in skeletal
muscle and heart and assessing their impact on neuromuscular disease progression. Other
work relates to the study of genes that stimulate skeletal muscle growth.
In addition, the laboratory works on projects involving the development
of therapeutics for Alzheimer’s
disease, the glycobiology of adult neural stem cells, and pediatric cancer.
Selected Publications:
- Xu, R., Chandrasekharan, K., Yoon, J.H., Camboni, M., and Martin,
P.T. (2007) Overexpression of the CT GalNAc transferase
inhibits muscular dystrophy in the dyW mouse model of congenital
muscular dystrophy 1A. Am. J. Pathol. 171:181-199.
- Martin, P.T. (2007) Congenital muscular dystrophies
involving the O-mannose pathway. Curr. Mol. Med., 7:417-425.
- Haidet, A.M., Rizo, L., Handy, C., Umapathi, P., Eagle, A., Shilling,
C., Boue, D., Martin, P.T., Sahenk, Z., Mendell, J.R.,
and Kaspar, B.K. (2008) Long-term enhancement of skeletal muscle mass
and strength by single gene administration of myostatin inhibitors. Proc.
Natl. Acad. Sci. USA 105: 4318-4322.
- Martin, P.T., Shelton, G.D., Dickinson, P.J., Sturges,
B.K., Xu, R., LeCouteur, R.A., Guo, L.T., Grahn, R.A., Lo, H.P., North,
K.N., Malik, R., Engvall, E., and Lysons, L.A. (2008) Muscular dystrophy
associated with alpha-dystroglycan deficiency in Sphynx and Devon Rex
cats. Neuromuscular Disorders 18:942-952.
- Kim, M-L., Chandrasekharan, K., Glass, M., Shi, S., Stahl, M., Kaspar,
B., Stanley, P., and Martin, P.T. (2008) O-fucosylation
of muscle agrin determines its ability to cluster acetylcholine receptors. Mol.
Cell. Neurosci. 39:452-464.
- Chandrasekharan, K. and Martin, P.T. (2009) Embryonic
overexpression of Galgt2 inhibits skeletal muscle growth via activation
of myostatin signaling. Muscle and Nerve, 39:25-41.
- Martin, P.T., Xu, R., Rodino, L.R., Oglesbay, E., Camboni,
M., Montgomery, C., Shontz, K., Chicoine, L, Clark, K.R., Sahenk, Z., Mendell,
J., and Janssen, P.M.L. (2009) Overexpression of Galgt2 in skeletal muscle
prevents injury resulting from eccentric contractions in both mdx and wild
type mice. Am. J. Physiol. Cell Physiol., 296:C476-488.
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